This calls for expeditious sampling when evidence of drug Urine and the window of detection is relatively short (3-10 h). Only about 1-5% of the dose of GHB is recoverable in GHB is then eliminated from plasma with a half-life of 30-50 min.
Owing to the availability of precursor drugs, γ-butyrolactone (GBL) and 1,4-butanediol (BD), which are not regulated.Īfter ingestion both GBL and BD are rapidly converted into GHB (t½ ~1 min). Although GHB is listed as a controlled substance in many countries abuse still continues, Indicates that GHB serves as a neurotransmitter or neuromodulator in the GABAergic system, especially via binding to Precursor and a metabolite of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Trace amounts of GHB are producedĮndogenously (0.5-1.0 mg/L) in various tissues, including the brain, where it functions as both a Medication for detoxification and withdrawal in alcoholics. The sodium salt of GHB is registered as a therapeutic agent (Xyrem®), approved in someĬountries for the treatment of narcolepsy-associated cataplexy and (Alcover®) is an adjuvant System depressant and is often encountered during forensic investigations of living and deceased The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous